A traction force threshold signifies metastatic phenotypic change in multicellular epithelia
نویسندگان
چکیده
منابع مشابه
Aneuploidy underlies a multicellular phenotypic switch.
Although microorganisms are traditionally used to investigate unicellular processes, the yeast Saccharomyces cerevisiae has the ability to form colonies with highly complex, multicellular structures. Colonies with the "fluffy" morphology have properties reminiscent of bacterial biofilms and are easily distinguished from the "smooth" colonies typically formed by laboratory strains. We have ident...
متن کاملHigh-resolution traction force microscopy.
Cellular forces generated by the actomyosin cytoskeleton and transmitted to the extracellular matrix (ECM) through discrete, integrin-based protein assemblies, that is, focal adhesions, are critical to developmental morphogenesis and tissue homeostasis, as well as disease progression in cancer. However, quantitative mapping of these forces has been difficult since there has been no experimental...
متن کامل3D Viscoelastic traction force microscopy.
Native cell-material interactions occur on materials differing in their structural composition, chemistry, and physical compliance. While the last two decades have shown the importance of traction forces during cell-material interactions, they have been almost exclusively presented on purely elastic in vitro materials. Yet, most bodily tissue materials exhibit some level of viscoelasticity, whi...
متن کاملMulticellular Architecture of Malignant Breast Epithelia Influences Mechanics
Cell-matrix and cell-cell mechanosensing are important in many cellular processes, particularly for epithelial cells. A crucial question, which remains unexplored, is how the mechanical microenvironment is altered as a result of changes to multicellular tissue structure during cancer progression. In this study, we investigated the influence of the multicellular tissue architecture on mechanical...
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ژورنال
عنوان ژورنال: Soft Matter
سال: 2019
ISSN: 1744-683X,1744-6848
DOI: 10.1039/c9sm00733d